約 3,627,418 件
https://w.atwiki.jp/hikaruforsetyboss/pages/12.html
前書き。 剣士系列 騎士 ロードナイト ピアースによる殲滅力、持ち前の高HPにより防御攻撃の両方が期待できる職。 ロードナイトはコンセントレーション、オーラブレイドも使え、さらに火力に磨きがかかり 全職の中でもTOPクラスの殲滅力をもつ。 クルセイダー パラディン グランドクロスはDOP、オシに有効、DOPでは無類の強さを誇る。 が、他のBossでは正直出番がない、オシDOP専用に作るのが良いだろう。 シーフ系列 アサシン アサシンクロス 正直Bossには向かない職。 アサシンクロスのEDP+付与のソニックブローは阿修羅並の威力はあるらしい。 ローグ チェイサー ヾ(´ー`* )ノ けどバックスタブは個人的に優秀スキルかとおもう。 対抗戦じゃ無理かな・・。 アコライト系列 プリースト ハイプリースト 言わずもがな、支援職。 いるいないとでBoss狩りの幅が広がります、正直必須職。 モンク チャンピョン 圧倒的破壊力を持つ職、高Lv優秀武器もちならば、LAありでBossを1発で沈めることも。 しかし消費も激しく、半端なレアだと赤字まわりになることも。 アーチャー系列 ハンター スナイパー こちらも圧倒的火力を持つ。 ハンターの神速DSはまさに圧巻。 スナイパーはTSも使えさらに火力に磨きがかかる。 だが、なんにせよ死にやすい、操作するプレイヤーの腕前が問われる。 ダンサー バード ジプシー クラウン アローバルカンは盾を持ちながら使えるため、耐える面ではハンターなどより上。 だが、ディレイが非常に長く厳しい。1発の威力はなかなか。 マーチャント系列 ブラックスミス ホワイトスミス 火力が非常にある、が現状のボスだと耐え切れず非常に厳しい。 が、ホワイトスミスには今後実装予定のカートターミネーションがあるため、化ける可能性も。 アルケミスト クリエーター コーティング最高、誰かの別キャラであると非常に助かります。 マジシャン系列 ウィザード ハイウィザード 火力をもっている、が死に安いのと高威力の魔法は範囲指定のため対抗がいると使いにくい。 が、ドレイクにおけるWBキャンセルは圧巻、非常に高い威力を誇る。 プロフェッサー セージ ディスペル、ランドプロテクターなど補助的なスキルをもつ。 現状ボスでは必要ないが、強化があるのなら必要になってくるのかもしれない。 Bossでの役割 騎士 ロードナイト 壁+攻撃、超Fleeなど攻撃が効かない場合は壁専念で。 対抗がいる時のスピアスタブも、間違っても見方にぶつけないよう。決壊とか恥ずかしいです。 ハンター スナイパー とにかく攻撃、常時DS、集中力向上などはこまめに使いなおしを。 対抗いる場合は火力として攻撃するか、CAでかく乱させるかは状況次第で。 自分も死にやすいので立ち回りには十分注意。 モンク チャンピョン とにかく阿修羅、対抗いる場合は任されることが多いと思うので、とにかく死なないようにかつ攻撃を。 SP薬は念入りに。 プリースト ハイプリースト 対抗がいる+見方にモンクがいる場合はLAをモンクの阿修羅にあわせましょう。 あるないで阿修羅だと相当、いやえらい違います。あるないでDropがひっくりかえったりします。 対抗がいない時でもBossに応じてリカバニューマなど使い分けること。 オシリス、バフォ等では前衛にアスペもしっかりと、見方が倒れたときのリザもできるだけはやく行う。 あと、イムポシティオマヌス積極的に使いましょう。 あるないで阿修羅のダメージ10kくらい変わります、けどディレイ長いので使いどころは見極めましょう。 ウィザード ハイウィザード ドレイクでは火力として、WBをうちまくりましょう。雑魚敵1匹もつことによりキャンセルWBが出るためかなり強いです。 他Bossでは取り巻き掃除+本体攻撃に勤めましょう。MSがベストです。 SGだとBossがあっちこっちに移動するため被害が出る恐れがあります。 ちなみにMSがきかない火属性BossではSGをがんがん狙っていきましょう。 火属性Bossは弱い+SGの高威力により相当なダメージを与えることができるので。
https://w.atwiki.jp/metalmetabo/pages/20.html
- visitors Sulfurtransferases 2010 Cell Biology of Molybdenum F Bittner, RR Mendel - Cell Biology of Metals and Nutrients, 2010 - Springer http //scholar.google.co.jp/scholar?q=related 1fBydctAk0cJ scholar.google.com/ hl=ja as_sdt=2000 Abstract The transition element molybdenum (Mo) is essential for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur,and nitrogen metabolism. The metal itself is biologically inactive unless it is complexed by a ... 2009 Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions nih.gov [HTML]A Noma, Y Sakaguchi, T Suzuki - Nucleic Acids Research, 2009 - Oxford Univ Press http //scholar.google.co.jp/scholar?q=related kS8aGPMvT5kJ scholar.google.com/ hl=ja as_sdt=2000 The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational rigidity of mcm 5 s 2 U by largely fixing the C3 -endo ribose puckering, ensuring stable ... Origin and function of ubiquitin-like proteins nih.gov [HTML]M Hochstrasser - Nature, 2009 - nature.com http //scholar.google.co.jp/scholar?q=related vqhk3w9krT0J scholar.google.com/ hl=ja as_sdt=2000 Eukaryotic proteins can be modified through attachment to various small molecules and proteins. One such modification is conjugation to ubiquitin and ubiquitin-like proteins (UBLs), which controls an enormous range of physiological processes. Bound UBLs ... 2008 Molybdoproteomes and evolution of molybdenum utilization nih.gov [HTML]Y Zhang, VN Gladyshev - Journal of molecular biology, 2008 - Elsevier http //scholar.google.co.jp/scholar?q=related g2yHxFnhe4AJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 The trace element molybdenum (Mo) is utilized in many life forms, and it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism. With the exception of nitrogenase, Mo is bound in proteins to a pterin, thus forming the molybdenum cofactor ( ... Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors nih.gov [HTML]N Shigi, Y Sakaguchi, S Asai, T Suzuki, K … - The EMBO Journal, 2008 - nature.com http //scholar.google.co.jp/scholar?q=related ARSfgx3Fp70J scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2010 2-Thioribothymidine (s 2 T), a modified uridine, is found at position 54 in transfer RNAs (tRNAs) from several thermophiles; s 2 T stabilizes the L-shaped structure of tRNA and is essential for growth at higher temperatures. Here, we identified an ATPase (tRNA-two-thiouridine ... The Sulfurtransferase Activity of Uba4 Presents a Link between Ubiquitin-like Protein Conjugation and Activation of Sulfur Carrier Proteins† J Schmitz, MM Chowdhury, P Hänzelmann, M … - Biochemistry, 2008 - ACS Publications http //scholar.google.co.jp/scholar?q=related tu5O65itnDEJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2010 Because of mechanistic parallels in the activation of ubiquitin and the biosynthesis of several sulfur-containing cofactors, we have characterized the human Urm1 and Saccharomyces cerevisiae Uba4 proteins, which are very similar in sequence to MOCS2A and MOCS3, respectively, ... Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems jbc.org [HTML]Y Nakai, M Nakai, H Hayashi - Journal of Biological Chemistry, 2008 - ASBMB http //scholar.google.co.jp/scholar?q=related rEPGgeDDU4AJ scholar.google.com/ hl=ja as_sdt=2000 The wobble uridine in yeast cytosolic tRNA Lys2 UUU and tRNA Glu3 UUC undergoes a thio-modification at the second position (s 2 modification) and a methoxycarbonylmethyl modification at the fifth position (mcm 5 modification). We previously demonstrated that the cytosolic ... An embarrassment of riches the enzymology of RNA modification nih.gov [HTML]D Iwata-Reuyl - Current opinion in chemical biology, 2008 - Elsevier http //scholar.google.co.jp/scholar?q=related 0tsj3spLBLEJ scholar.google.com/ hl=ja as_sdt=2000 The maturation of transfer RNA (tRNA) involves extensive chemical modification of the constituent nucleosides and results in the introduction of significant chemical diversity to tRNA. Many of the pathways to these modified nucleosides are characterized by chemically complex ... A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae cshlp.org [HTML]B Huang, J Lu, AS Byström - Rna, 2008 - rnajournal.cshlp.org http //scholar.google.co.jp/scholar?q=related 4xQVocA9SD4J scholar.google.com/ hl=ja as_sdt=2000 We recently showed that the γ-subunit of Kluyveromyces lactis killer toxin (γ-toxin) is a tRNA endonuclease that cleaves , , and 3′ of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U). The 5-methoxycarbonylmethyl ... 2007 Biosynthesis of the Thio-quinolobactin Siderophore an Interesting Variation on Sulfur Transfer nih.gov [HTML]AM Godert, M Jin, FW McLafferty, TP … - Journal of …, 2007 - Am Soc Microbiol http //scholar.google.co.jp/scholar?q=related EBTZm24E50AJ scholar.google.com/ hl=ja as_sdt=2000 Text 15 Thio-quinolobactin, 8-hydroxy-4-methoxy-thioquinaldic acid (structure 1), is a 16 ... 17400.(10-12) The genes responsible for the biosynthesis of thio-quinolobactin have 18 ... There are a number of naturally occurring molecules of diverse structure that 27 A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast cshlp.org [HTML]GR Björk, B Huang, OP Persson, AS Byström - Rna, 2007 - rnajournal.cshlp.org http //scholar.google.co.jp/scholar?q=related ufP8yaCqiVsJ scholar.google.com/ hl=ja as_sdt=2000 Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm 5 s 2 U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In ... 2006 Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain DG Waterman, M Ortiz-Lombardía, MJ Fogg, EV … - Journal of molecular …, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related j-_C2YkFA-IJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 ThiI is an enzyme responsible for the formation of the modified base S 4 U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This base acts as a sensitive trigger for the response mechanism to UV exposure, providing protection against its damaging effects. We ... Trafficking in persulfides delivering sulfur in biosynthetic pathways EG Mueller - Nature Chemical Biology, 2006 - nature.com http //scholar.google.co.jp/scholar?q=related ZzZgR5SebvcJ scholar.google.com/ hl=ja as_sdt=2000 The presence of sulfur in cofactors has been appreciated for over a century, but the trafficking and delivery of sulfur to cofactors and nucleosides is still not fully understood. In the last decade, great strides have been made toward understanding those processes and the ... Cell biology of molybdenum RR Mendel, F Bittner - Biochimica et Biophysica Acta (BBA)-Molecular …, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related C6ckangyps8J scholar.google.com/ hl=ja as_sdt=2000 The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism. The metal itself is biologically inactive unless it is complexed by ... The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains biomedcentral.com [HTML]LM Iyer, AM Burroughs, L Aravind - Genome Biology, 2006 - biomedcentral.com http //scholar.google.co.jp/scholar?q=related UgYKXG9Yy80J scholar.google.com/ hl=ja as_sdt=2000 Ubiquitin (Ub)-mediated signaling is one of the hallmarks of all eukaryotes. Prokaryotic homologs of Ub (ThiS and MoaD) and E1 ligases have been studied in relation to sulfur incorporation reactions in thiamine and molybdenum/tungsten cofactor biosynthesis. However, there is no ... Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions cell.com [HTML]Y Ikeuchi, N Shigi, J Kato, A Nishimura, T Suzuki - Molecular cell, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related 2Vsoqag0uDsJ scholar.google.com/ hl=ja as_sdt=2000 The wobble bases of bacterial tRNAs responsible for NNR codons are modified to 5-methylaminomethyl-2-thiouridine (mnm 5 s 2 U). 2-thio modification of mnm 5 s 2 U is required for accurate decoding and essential for normal cell growth. We identified five genes yhhP, ... 2005 Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs implications for the molecular … jbc.org [HTML]N Umeda, T Suzuki, M Yukawa, Y Ohya, H … - Journal of Biological …, 2005 - ASBMB http //scholar.google.co.jp/scholar?q=related l9eGdubEKOEJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 Human mitochondrial (mt) tRNA Lys has a taurine-containing modified uridine, 5-taurinomethyl-2-thiouridine ( m 5 s 2 U), at its anticodon wobble position. We previously found that the mt tRNA Lys , carrying the A8344G mutation from cells of patients with myoclonus ... l-Cysteine Desulfidase An [4Fe-4S] Enzyme Isolated from Methanocaldococcus jannaschii That Catalyzes the Breakdown of l-Cysteine into Pyruvate, Ammonia, and … SI Tchong, H Xu, RH White - Biochemistry, 2005 - ACS Publications http //scholar.google.co.jp/scholar?q=related QUO6D5wSaMQJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 A [4Fe-4S] enzyme that decomposes l-cysteine to hydrogen sulfide, ammonia, and pyruvate has been isolated and characterized from Methanocaldococcus jannaschii. The sequence of the isolated enzyme demonstrated that the protein was the product of the M. jannaschii ... Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis nih.gov [HTML]KE Burns, S Baumgart, PC Dorrestein, H Zhai, … - J. Am. Chem. …, 2005 - ACS Publications http //scholar.google.co.jp/scholar?q=related 6UxhZ1K_8BAJ scholar.google.com/ hl=ja as_sdt=2000 A new pathway for cysteine biosynthesis has been elucidated in Mycobacterium tuberculosis. This pathway involves a protein-bound thiocarboxylate (CysO−SH) as the sulfide donor, similar to thiamin biosynthesis. Cysteine synthase M (CysM) catalyzes the addition ... 2004 Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans pnas.org [HTML]A Matthies, KV Rajagopalan, RR … - Proceedings of the …, 2004 - National Acad Sciences http //scholar.google.co.jp/scholar?q=related PpXEO3soBo0J scholar.google.com/ hl=ja as_sdt=2000 Recent studies have identified the human genes involved in the biosynthesis of the molybdenum cofactor. The human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein and a C-terminal segment displaying similarities to the ... Ubiquitin-proteasome system umaryland.edu [PDF]S Fang, AM Weissman - Cellular and molecular life sciences, 2004 - Springer http //scholar.google.co.jp/scholar?q=related UwB61_LeFJAJ scholar.google.com/ hl=ja as_sdt=2000 Abstract. The capacity for exquisite regulation of ubiq- uitylation provides eukaryotic cells with a means to fine- tune both protein function and levels. This complex set of processes affects myriad proteins and potentially impacts all cellular processes. Ubiquitylation is brought about ... 2003 Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p nih.gov [HTML]AS Goehring, DM Rivers, GF Sprague Jr - Eukaryotic cell, 2003 - Am Soc Microbiol http //scholar.google.co.jp/scholar?q=related NuIwzhoOL5cJ scholar.google.com/ hl=ja as_sdt=2000 Urm1p is a ubiquitin-related protein that serves as a posttranslational modification of other proteins. Urm1p conjugation has been implicated in the budding process and in nutrient sensing. Here, we have identified the first in vivo target for the urmylation pathway as the ... 2002 The rhodanese/Cdc25 phosphatase superfamily nih.gov [HTML]D Bordo, P Bork - EMBO reports, 2002 - nature.com http //scholar.google.co.jp/scholar?q=related OxriJBcqB5AJ scholar.google.com/ hl=ja as_sdt=2000 ... In this review, the rhodanese/Cdc25 phosphatase superfamily is analyzed. ... Figure 3 Neighbor-joining tree representing the rhodanese superfamily generated by CLUSTALW (correction for ... Catalytically active rhodanese and Cdc25 phosphatase domains The N- and C- ... 2001 A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli jbc.org [HTML]S Leimkühler, KV Rajagopalan - Journal of Biological Chemistry, 2001 - ASBMB http //scholar.google.co.jp/scholar?q=related q8ya_wsSejkJ scholar.google.com/ hl=ja as_sdt=2000 It has been shown that conversion of precursor Z to molybdopterin (MPT) by Escherichia coli MPT synthase entails the transfer of the sulfur atom of the C-terminal thiocarboxylate from the small subunit of the synthase to generate the dithiolene group of MPT and that the moeB ... M ECHANISMS U NDERLYING U BIQUITINATION uky.edu [PDF]CM Pickart - Annual review of biochemistry, 2001 - Annual Reviews http //scholar.google.co.jp/scholar?q=related YIxzrFekkFQJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2001 Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination reactions reflect the properties of enzymes known as ubiquitin-protein ligases or E3s. An E3 recognizes its ... 2000 Evolution and function of ubiquitin-like protein-conjugation systems yale.edu [PDF]M Hochstrasser - Nature cell biology, 2000 - nature.com http //scholar.google.co.jp/scholar?q=related w2aIi7-UqxoJ scholar.google.com/ hl=ja as_sdt=2000 Cellular proteins are frequently adorned with chemical modifications that alter their physical — and, as a result, their physiological — properties. Among the most spectacular of these molecular appendages are grafts of other proteins or even polymeric chains of other proteins. The ... A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes jbc.org [HTML]K Furukawa, N Mizushima, T Noda, Y … - Journal of Biological …, 2000 - ASBMB http //scholar.google.co.jp/scholar?q=related kWwdzGB67rIJ scholar.google.com/ hl=ja as_sdt=2000 Protein conjugation, such as ubiquitination, is the process by which the C-terminal glycine of a small modifier protein is covalently attached to target protein(s) through sequential reactions with an activating enzyme and conjugating enzymes. Here we report on a novel protein ... 1998 Cysteine Sulfinate Desulfinase, a NIFS-like Protein of Escherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities Gene Cloning, Purification and … kyoto-u.ac.jp [PDF]N Esaki, T Kurihara, T Yoshimura, K … - ICR annual …, 1998 - repository.kulib.kyoto-u.ac.jp http //scholar.google.co.jp/scholar?q=related QtLum1tHQrQJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. Kyoto University KURENAI Kyoto University Research Information Repository Title Cysteine Sulfinate Desulfinase, a NIFS-like Protein of Escherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities ... 1997 Cysteine Sulfinate Desulfinase, a NIFS-like Protein ofEscherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities jbc.org [HTML]H Mihara, T Kurihara, T Yoshimura, K Soda, N … - Journal of Biological …, 1997 - ASBMB http //scholar.google.co.jp/scholar?q=related bOaL5q7FBDoJ scholar.google.com/ hl=ja as_sdt=2000 Selenocysteine lyase (EC 4.4.1.16) exclusively decomposes selenocysteine to alanine and elemental selenium, whereas cysteine desulfurase (NIFS protein) of Azotobacter vinelandii acts indiscriminately on both cysteine and selenocysteine to produce elemental sulfur and selenium ... 1991 Characteristics of Nicotiana tabacum nitrate reductase protein produced in Saccharomyces cerevisiae. nih.gov [PDF]HN Truong, C Meyer, F Daniel-Vedele - Biochemical Journal, 1991 - ncbi.nlm.nih.gov http //scholar.google.co.jp/scholar?q=related 8oijnWbQUp4J scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 INTRODUCTION Tobacco nitrate reductase (NR) (EC 1.6.6.1) is a homodimeric enzyme that reduces nitrate to nitrite in the presence of NADH (NADH NR activity). Each of its subunits contains three domains carrying respectively the prosthetic groups FAD, haem (cytochrome b-557) ... UBA 1 an essential yeast gene encoding ubiquitin-activating enzyme. nih.gov [PDF]JP McGrath, S Jentsch, A Varshavsky - The EMBO journal, 1991 - ncbi.nlm.nih.gov http //scholar.google.co.jp/scholar?q=related qFlUGfxF0asJ scholar.google.com/ hl=ja as_sdt=2000 The EMBO Journal vol.10 no.1 pp.227-236, 1991 ... UBA 1 an essential yeast gene encoding ubiquitin- ... John P.McGrath, Stefan Jentsch and Alexander Varshavsky ... Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Present ...
https://w.atwiki.jp/soraneko/pages/14.html
Paper man 公式HP WikiHP Paper man Wiki Paper man ※クローズドβテスター募集中。
https://w.atwiki.jp/thesimssocial/pages/188.html
Paper リクエスト AskFriend/NewsFeed(不明) 入手方法 WriteSkill Moneywell GT3060 WriteSkill Hunt N Peck T5a WriteSkill Hunt N Peck GT WriteSkill Couplet Poet Pro WriteSkill Moneywell RSi WriteSkill AMour Edition Typewriter
https://w.atwiki.jp/xbox360gta4/pages/214.html
PAPER TRAIL ~~~ミッション開始時、U.L.Paperから着信~~~ U.L.Paper Bellic. We need you. Now! The chopper is prepped and waiting off Grummer Road in Northwood. Your sometime accomplice, Jacob, is there. He s riding shotgun on this one. Belic君、今こそお前の出番だ!ヘリがNorthwoodのGrummer Road付近で待機中だ。お前のツレのJacobもそこにいる。ショットガンを持ってな。 Niko Jacob? The rasta? Jacobだって?ジャマイカ人の? U.L.Paper Don t ask unnecessary questions. I want you to take out this guy s chopper. He was last spotted in Varsity Heights. No civillian casualties. 余計な詮索は無しだ。奴のヘリを墜としてやれ!最終目撃地点はVarsity Heightsだ!犠牲者は出すな! ~~~指令・Meet Jacob at the salvage yard of Crummer Road. Crummer Roadの海難救助港にてJacobに会え。 ~~~現場到着~~~ Little Jacob Yes, here s my man Niko. よっしゃ、我らがNiko様参上!ってな。 Niko Hey, Jacob. よぉ、Jacob. ~~~指令・The target and wait for an opportunity to take down his helicopter. Fly south and locate the target chopper. Follow the target and wait for an opportunity to take down his helicopter. ターゲットを捕捉し、撃墜の機会を窺え。 LJ Yo Niko, got some serious fire power up in here. Rocket launcher! Bro! おいNiko、ここにすげぇぶきがあるぜ!ロケットランチャーだ!兄弟! Niko Let s find him and get this over with. I don t like being in this man s pocket. 早いとこ奴を見つけてぶっ潰してやろうぜ。奴の懐に居続けるのはゴメンだからな。 LJ Ain t nuthin but badda badda そうこなくっちゃな! ~~~指令・Follow the target chopper, don t let it get away.~~~ ヘリを追え。決して逃がすな! LJ There be the other chopper. Stick to him, Niko. We need to take him down where there be no people. あそこにヘリが飛んでる。Niko、あいつに接近しろ。人気のないところで撃墜させる必要があるんだ。 Niko For a man who has asked me to kill a lot of men, this guy is really safety conscious. 俺に多くの人殺しを依頼した男にしては随分安全意識が高いんだな。 LJ See. He got that government ting about him. All for the greater good and ting. まあ、役人魂ってやつさ。すべてはより良い社会のためにってな。 Niko I have the feeling he don t want to be responsible for a helicoptor crash in Middle park. あいつ、Middle Parkでヘリコプター事故が起きても責任は取らないだろうな。 LJ True da! Yo, dis be some crazy shit ya know Niko. Yo, we inna the Star Junction in a helicopter. Dis some real spy shit I nd I is doing ya know. その通りさ!おい、こりゃハンパねーな、Niko。今俺達はヘリでStar Junctionを通過中だ。俺らのやってることって、まるでスパイみてぇだよな。 Niko Shows you the people who need spy shit done get other people to do their dirty work. スパイの必要な人間は汚い仕事を人に押し付けるモンだってことだな。 LJ Seen, bredron. Everything crash! あちゃあ、メチャクチャだな。 Niko Shit, Jacob. You really gotta smoke that thing now? The secondary somoke doesn t exactly help my hand-eye coordination. And I m paranoid enough with US gobernment on my ass. Whatever actually, just somoke it. おいおい、Jacob.こんなときにまで吸うのか?副流煙のせいで手元が狂っちまうよ。おまけに俺は政府に追われてて十分パラノイアなんだけどな。まあどうでもいいや。どうぞ吸ってくれ。 ~~~相手ヘリを追って橋の下をくぐるとJacobタンから以下のお褒めの言葉~~~ LJ Rhaaatid! What a gwan? ひゃっほーう!全く何て操縦だ! Niko Don t worry about the bridge, Jacob. I m finally getting the hang of flying this thing. 橋のことなら心配するなよ、Jacob.やっとこれを飛ばすコツがつかめてきたんだ。 LJ Yo Respect! Ya a rightous rudeboy, Niko. Get close so I can take a shot! すげぇな!マジで正真正銘のブッ飛び野郎だぜ、Niko.さぁ奴に近づいてくれ。こいつをぶっ放してやるぜ! ~~~指令・Get close and move to the right of the target chopper to give Jacob a shot.~~~ ヘリに接近しJacobの攻撃が当たるように右端に寄れ。 ~~~ターゲットヘリ狙撃中~~~ LJ Keep steady for de shot now. Cha missed the ras clot. Get me back in I spot. Steady now man, me need to shoot! よし、撃つぞ。揺らさないでくれよ。チッ、しくじった!戻ってくれ。揺らさないでくれよ、今度こそヤッてやる! Niko You gotta work on your aim, Jacob. I could have made that shot with my eyes closed. よく狙ってくれよ、Jacob. 今のは俺なら目を瞑ってたって当たったぞ。 LJ How am I gonna get dis bumba clot with ya moving all over de place? どうやったらこんなにあちこち動いてる中で撃ち落とせるんだよ? ~~~撃墜後~~~ LJ Feel de fiyaah. あの世に逝きな。 Niko Good shot, Jacob. ナイスショット、Jacob. LJ Ya got some crucial flying skills, ya know Niko. Can I drop I off on de heli pad though? Me no feel so good ya know.Trust me, dis ting a mess wit me structure. お前も素晴らしい操舵術だったじゃまいか!そうだろNiko.あ~、悪いが俺をヘリポートで降ろしてくれるか?気持ち悪いんだよマジで。あ~ぁクラクラするぅ~。 ~~~指令・Drop Jacob at the helipad off Union Drive East. Union Drive EastでJacobを降ろせ。 LJ Yo, job well done ya know Niko, but we haffi get out dis bumba clot debt right now, ya know. Niko、仕事は上手くいった。でも早くここから離れなきゃな。 Niko I do not think he can ask us to do more than this. Now it is our turn to get him to help us. If someone can find the ma I search for, it should be him. あの男はこれ以上のことは俺達に要求してこないだろう。今度はヤツが俺達を助ける番だ。もし、オレの捜してる裏切者を見つけ出せるやつがいるとしたら、それはヤツしかいない。 LJ Let s do it. さあやろうぜ。 ~~~ヘリ着陸後~~~ LJ Wicked Niko, ya don t know, ya de man, ya know? Sight de man soon, seen? すげえぜNiko,お前って奴はまったくよ。またな。 ~~~U.L.Paperに電話~~~ Niko We shot down that chopper for you. ヘリは撃墜してやったぜ。 U.L.Paper You think I don t know that? You think I ve been sitting around scratching my balls with my head up my ass. んなこたぁ分かってるさ。君が仕事をしている間、私がえびぞりしながらオナニーでもしてたとでも思っているようだな。 Niko I d be impressed if you had been. もしそうなら大感激だ。 U.L.Paper I appreciale your assistance, Bellic. You did a good thing loday. Now it s my turn. I will try to find the man you re after. I will call when I have something. 君の助力に感謝するよ、Belic君。君は善いことをしたね。今度は私の番だ。君が捜している人について何か分かったら連絡するよ。
https://w.atwiki.jp/metalmetabo/pages/16.html
Chemical genomics - visitors 2010 Propranolol and the risk of hospitalized myopathy Translating chemical genomics findings into population-level hypotheses S Setoguchi, JM Higgins, H Mogun, VK Mootha, J … - American Heart …, 2010 - Elsevier http //linkinghub.elsevier.com/retrieve/pii/S0002870309009624 New users of propranolol and other β-blockers (BBs) aged ≥65 were identified using data from Medicare and drug benefit programs in 2 states (1994-2005). The primary end point studied was hospitalization for myopathy or rhabdomyolysis. We used stratified Cox proportional ... Identification of an ABCB/P-glycoprotein-specific inhibitor of auxin transport by chemical genomics JY Kim, S Henrichs, A Bailly, V Vincenzetti, V … - Journal of Biological …, 2010 - ASBMB http //www.jbc.org/content/early/2010/05/14/jbc.M110.105981.full.pdf From the Laboratory of Plant Systems Bio-Dynamics, Pohang University of Science Technology, Pohang, Republic of Korea1,University of Zurich and Zurich-Basel Plant Science Center, Institute of Plant Biology, Zurich, Switzerland2, Department of Horticulture, ... Physcion-8-O-β-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation Possible involvement of … SU Lee, YH Choi, YS Kim, SJ Park, HB … - Journal of Cellular …, 2010 - interscience.wiley.com ... 1 Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea 2 Department of Biology, Chungnam National University, Daejeon 305-765, Korea 3 Laboratory of Phytochemistry Research, Korea Research Institute of Chemical ... Preparation and characterization of monodisperse CdS quantum dot-polymer microspheres Q Shao, C Yang, L Jiang, J He, S … - Journal of Polymer …, 2010 - interscience.wiley.com ... 1 Nano-Micro Materials Research Center, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China 2 Shenzhen Key Laboratory of Special Functional Materials, Shenzhen ... Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation ML Sos, HB Rode, S Heynck, M Peifer, F Fischer, S … - Cancer Research, 2010 - AACR ... Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, 2 Center of Integrated Oncology and Department I of Internal Medicine, University of Köln, Cologne, Germany; 3 Chemical Genomics Centre of the Max ... Inside Cover A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety (ChemMedChem 5/2010) MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com ... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax (+1) 301-217-5736. email Craig J. Thomas (craigt@mail.nih.gov). ... A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com ... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax (+1) 301-217-5736. email Craig J. Thomas (craigt@mail.nih.gov). ... A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor S Neumann, W Huang, E Eliseeva, S Titus, CJ … - Endocrinology, 2010 - Endocrine Soc ... Clinical Endocrinology Branch (SN, EE, MCG), National Institute of Diabetes and Digestive and Kidney Diseases, and National Institutes of Health (NIH) Chemical Genomics Center (WH, ST, CJT), National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 ... Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx S Terry, C Austin, J Inglese, D Meeker, … - Assay and drug …, 2010 - liebertonline.com ... Christopher Austin NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. James Inglese NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. ... A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana M Serrano, DA Hubert, JL Dangl, P Schulze-Lefert, E … - Planta, 2010 - Springer Page 1. ORIGINAL ARTICLE A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana Mario Serrano • David A. Hubert • Jeffery L. Dangl • Paul Schulze-Lefert • Erich Kombrink ...
https://w.atwiki.jp/drip122/pages/27.html
JBossを使う JBoss EAPは、JBoss Enterprise Application Platformの略。 JBoss ASは、JBoss Application Serverの略。
https://w.atwiki.jp/mtgwiki/pages/1023.html
Paper 主にマスクス・ブロック構築に存在したデッキ。 #whisper #whisper #whisper 序盤はぶどう棚/Vine Trellisなどでマナ加速をし、そこからスカイシュラウドの要求/Skyshroud Claimでランドブーストをする。 さらにスカイシュラウドの要求で場に出た森で生き返り/Reviveをプレイし、スカイシュラウドの要求を回収して再びプレイ、と大量に森を並べていく。 そして土地が並んだところで、自然の類似/Natural Affinityで土地をクリーチャー化して対戦相手を殴り倒す。 また、大量に並んだ土地を活かしてスカイシュラウドの歩哨/Skyshroud Sentinelや遠吠えする狼/Howling Wolf、巣ごもりワーム/Nesting Wurmといった重いが同名のカードをサーチするクリーチャーも利用される。 緑単色のものも存在するが、青緑で組まれることが多い。 青を用いる理由は、自然の類似後のアタックを通すために陥穽/Ensnareを使うためである。 攻撃クリーチャーを指定した後に攻撃クリーチャー指定ステップで使用すれば、自然の類似でクリーチャー化した対戦相手の土地にブロックされずに攻撃を通すことができる。 また、強力なドロー ライブラリー操作カードである渦まく知識/Brainstormなども使われる。 上記のスカイシュラウドの歩哨などを出して同名のカードを3枚手札に入れた後、渦まく知識でうち2枚をライブラリーに戻し、残りの1枚をプレイしてこの2枚を再び手札に入れる、といった小技もある。 参考 An Unnatural Affinity デッキ集
https://w.atwiki.jp/kanekotky/pages/4.html
JBoss Seam SeamとWebアプリケーションのアーキテクチャについて JJBug http //www.jbug.jp/cgi-bin/fswiki/wiki.cgi ドキュメント Getting Started日本語訳 JBoss 2.2+ ドキュメンテーション日本語版 JBoss Cache JBoss Issue The JBoss Issue Rickard Oberg creates TheJBossIssue blog? The Serverside.com 大特集 JBossの全て(JavaWorld 2006/03月号) JBossを深く知るための10のポイント NRIの黒澤さんの記事。 JBossの特徴が良く分かり、最近のJBossの流れも良く分かるのでお薦め。 ただポイントかなぁという物もあるので、10個は多すぎな気がする。 JBossで学ぶEJB3.0アプリ開発 沖林さんの記事。 DVD Storeアプリの紹介と、EJB3.0の実装概要。AOPの使い方はさらっと。 JBoss Microcontainerの紹介がコラムにあった。JBoss MicrocontainerはTomcatや他のAPサーバ上でも動く軽量コンテナ。SpringやSeasar2に近い。 システム運用/管理機能の実力を探る HPの水野さん、佐藤さんの記事。 モニタリング/アラート機能はとても使える。管理コンソールにアクセス制御をかける話は、実環境では必ずやらないとダメ。ログの動的出力レベル変更方法や、JBossの自動起動の話などかなりお薦め。 パフォーマンス・チューニングの勘所 引き続き水野さんと佐藤さんの記事。 細かいところでは説明が物足りないが、ポイントは抑えられている。実際問題、単体ではそんなにチューニングする箇所は無いし。クラスタの方はまだ考える事がありそう。 単体最大/最小スレッドの最適化 過剰なログ出力の抑制 クラスローダの共通化 不要なリソースの削除 メソッド呼び出し方法の変更 JDBC接続数の最適化 クラスタセッション・レプリケーション JBoss Cacheを最新版に更新 JGroupsのバッファ・サイズを拡張 Stateful Session Beanのレプリケーション・タイミングの最適化 WebアプリケーションのクラスローダをJBossが提供しているものに変えた方が速いというのは、初耳。試してみないと。 主要周辺プロダクトを試す 豆蔵の人たちの記事。JBoss Portalは触った事がないので勉強になりました。簡単にポータルページが作れそう。しかも見た目綺麗。 JBoss IDEは、どうなんだろう?WTPとかと被る部分を除くと、残るのはXDocletくらいだろうか。 JBoss Cacheについてはかなり詳しく解説。JBoss Advanced Trainingの内容に近い。読み応えがあります。 JBoss Seamについても解説。JSFとEJB3.0 or Hibernateを繋ぐSeam。サンプルを使って繋ぎ方を解説。 JBoss Serialization Javaの遅いSerializationを速くするプロジェクトのようだが・・・ ファイルに書き出すプログラムTest.javaで試してみたところ、10倍くらい遅い。書く量も多すぎ。何で? Demo JBoss Suites Seam Framework DVD Store Bug Transaction Leak in JDBCStateManagerLeakしているらしいが、JDBCStateManagerって何だろう。 News OSC 2006 Tokyo/Spring - JBossとOSS、第2の開発モデルとビジネス戦略 テンアートニと米国JBoss 社、戦略的パートナー契約を締結~JBoss製品のサポートサービス及び国内初の認定エンジニアトレーニングサービスの提供を開始~ 米JBoss,メッセージング基盤「JBoss Messaging」とWebサーバー「JBoss Web」を公開 JEMSをさらに強化 - JBoss jBPM、JBoss Rules、JBoss Transactins最新版 Apache HTTPのライバル出現? - JEMSを強化JBoss Messaging、JBoss Web その他 Firewall越しの設定ポート JGroups Logging
https://w.atwiki.jp/apex/pages/16.html
Papaya "Papaya Leaf" The humble papaya is gaining credibility in Western medicine for anticancer powers that folk cultures have recognized for generations. University of Florida researcher and a professor of medicine Nam Dang, M.D., Ph.D., and colleagues in Japan have documented papaya’s dramatic anticancer effect against a broad range of lab-grown tumors, including cancers of the cervix, breast, liver, lung and pancreas. The researchers used an extract made from dried papaya leaves, and the anticancer effects were stronger when cells received larger doses of the tea. In a paper published in the Feb. 17 issue of the Journal of Ethnopharmacology, Dang and his colleagues also documented for the first time that papaya leaf extract boosts the production of key signaling molecules called Th1-type cytokines. This regulation of the immune system, in addition to papaya’s direct antitumor effect on various cancers, suggests possible therapeutic strategies that use the immune system to fight cancers. Nam Dang, M.D., Ph.D., a professor of medicine and medical director of the UF Shands Cancer Center Clinical Trials Office. The papaya extract did not have any toxic effects on normal cells, avoiding a common and devastating consequence of many cancer therapy regimens. The success of the papaya extract in acting on cancer without toxicity is consistent with reports from indigenous populations in Australia and his native Vietnam, said Dang, who is also medical director of the UF Shands Cancer Center Clinical Trials Office. “Based on what I have seen and heard in a clinical setting, nobody who takes this extract experiences demonstrable toxicity; it seems like you could take it for a long time — as long as it is effective,” he said. Researchers exposed 10 different types of cancer cell cultures to four strengths of papaya leaf extract and measured the effect after 24 hours. Papaya slowed the growth of tumors in all the cultures. To identify the mechanism by which papaya checked the growth of the cultures, the team focused on a cell line for T lymphoma. Their results suggested that at least one of the mechanisms employed by the papaya extract is inducing cell death. In a similar analysis, the team also looked at the effect of papaya extract on the production of antitumor molecules known as cytokines. Papaya was shown to promote the production of Th1-type cytokines, important in the regulation of the immune system. For that reason, the study findings raise the possibility of future use of papaya extract components in immune-related conditions such as inflammation, autoimmune disease and some cancers. Bharat B. Aggarwal, Ph.D., a researcher at the University of Texas M.D. Anderson Cancer Center in Houston, already is so convinced of papaya’s restorative powers that he has a serving of the fruit every day. “We have always known that papaya has a lot of interesting things in there,” said Aggarwal, a professor in the center’s department of experimental therapeutics who was not involved in the UF research. Foremost among papaya’s health-promoting agents is papain, papaya’s signature enzyme, which is found in both the fruit and the leaves. “This paper has not gone too much into identifying the components responsible for the activity, which is just fine. I think that is a good beginning,” Aggarwal said. Aggarwal also noted that papaya extract’s success in reducing cancer in laboratory cell cultures must next be replicated in animal and human studies. “I hope Dr. Dang takes it further, because I think we need enthusiastic people like him to move it forward,” Aggarwal said. Dang and a colleague have applied to patent the process to distill the papaya extract through the University of Tokyo; the next step in the research is to identify the specific compounds in the papaya extract active against the cancer cell lines. For this stage, Dang has partnered with Hendrik Luesch, Ph.D., a fellow UF Shands Cancer Center member and a professor of medicinal chemistry. Luesch is an expert in the identification and synthesis of natural products for medicinal purposes, and recently discovered a coral reef compound that inhibits cancer cell growth in cell lines.